Short answer
Yes. USCIS can compare your filing with information from its own records, other government systems, public sources, and investigative work. Whether the agency contacts a particular employer, landlord, bank, or other private party depends on the individual case. The practical lesson is that an immigration filing does not exist in isolation. Make sure the current filing is accurate and consistent with information that can be verified elsewhere. Prior filings, addresses, employment, and other verifiable facts can all become points of comparison.
Official technical source
DHS/USCIS Privacy Impact Assessment, Fraud Detection and National Security Data System
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A short general answer cannot account for every immigration history or risk factor.